|
KMID : 1134820150440121785
|
|
Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 12 p.1785 ~ p.1792
|
|
|
Anti-Diabetic, Alcohol Metabolizing Enzyme, and Hepatoprotective Activity of Acer tegmentosum Maxim. Stem Extracts
|
|
Cho Eun-Kyung
Jung Kyong-Im
Choi Young-Ju
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the antidiabetic, alcohol metabolism, anti-inflammatory, and hepatoprotective effects of Acer tegmentosum extracts (ATE). A. tegmentosum has been traditionally used as a folk medicine to treat hepatic disorders. The antioxidative activities of ATE were measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and superoxide (SOD) assay. DPPH radical scavenging and SOD activities of ATE were about 89% and 82.9% at 0.5 μg/mL, respectively. Alcohol dehydrogenase and acetaldehyde dehydrogenase activities were 118.0% and 177% at 2 mg/mL, respectively. α-Glucosidase inhibitory activity of ATE was 75% higher at 50 μg/mL and remarkably increased in a dose-dependent manner. Nitric oxide productions in macrophage RAW 264.7 cells stimulated by lipopolysaccharide was reduced to 16.7% by addition of ATE at 1 mg/mL. ATE showed significant protective effects against tacrine-induced cytotoxicity in Hep G2 cells at 100 μg/mL. Based on our results, we conclude that ATE may be used as a major pharmacological agent and anti-diabetic, anti-hepatitis, and anti-inflammatory remedy.
|
|
|
KEYWORD
|
|
|
Acer tegmentosum, anti-inflammatory, α-glucosidase, alcohol dehydrogenase, hepatoprotective
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|